CoE for advanced Nanobiomaterials and Technologies (CoE-NBT) – Lecce, CNR

The CoE for advanced Nanobiomaterials and Technologies is aimed to develop and validate tissue engineering and regenerative medicine solutions based on the use of the most advanced technologies of nano- and microfabrication, additive manufacturing, delivery, sensing and imaging, for the production and standardization of next-generation implantable and injectable biomaterials for tissue repair and translational medicine. CoE-NBT will be strategically placed inside the CNR-Nanotec’s infrastructure of Lecce (12,000 m2 of labs organized in 7 open access facilities for advanced materials and nanotechnology) hosting, since 2018, the Technopole for Precision Medicine (TecnoMED-Puglia) (3,000 m2 of open access laboratories focused on 4 technological platforms: liquid biopsy, high-resolution imaging, nanomedicine, in vitro 3D models). Therefore, CoE-NBT will integrate and further enhance the mature scientific and high-technological skills in Life Sciences & Health sector available in the surrounding ecosystem.

CoE-NBT will be equipped with state-of-the art instrumentation and organized in 3 open access facilities usable to external researchers and companies at national and European level. Biofabrication Lab: devoted to the fabrication of implantable and injectable 3D biomimetic scaffolds. Including, high-resolution digital light processing printers, 3D printers based on fused polymer deposition or two-photon polymerization, computer numerical control micromilling, laser-FIB, reactive ion etching, laser lithography. Nanomaterials Lab: devoted to the synthesis of nano- and microparticles. Including, robotic combinatorial synthesis of nanoparticles; automated microwave peptide synthesizer; tangential flow filtration system; high performance liquid and gel permeation chromatography systems for preparative- to analytical-scale isolation, purification, and analysis of multiple types of (bio)molecules. Characterization Lab: devoted to full characterization of nano- and microparticle-integrated 3D biomimetic scaffolds and study of their interactions with living systems. Including, fourier-transform infrared spectroscopy, thermogravimetric analysis, proton nuclear magnetic resonance, atomic force microscope and related spectroscopy, multiphoton microscopy and fluorescence lifetime imaging microscopy, fluorescence activated cell sorting, real-time live-cell metabolic assay platform, raman spectroscopy, cryogenic electron microscopy, secondary ion mass spectrometry.