The CoE for advanced Nanobiomaterials and Technologies is aimed to develop and validate tissue engineering and regenerative medicine solutions based on the use of the most advanced technologies of nano- and microfabrication, additive manufacturing, delivery, sensing and imaging, for the production and standardization of next-generation implantable and injectable biomaterials for tissue repair and translational medicine. CoE-NBT will be strategically placed inside the CNR-Nanotec’s infrastructure of Lecce (12,000 m2 of labs organized in 7 open access facilities for advanced materials and nanotechnology) hosting, since 2018, the Technopole for Precision Medicine (TecnoMED-Puglia) (3,000 m2 of open access laboratories focused on 4 technological platforms: liquid biopsy, high-resolution imaging, nanomedicine, in vitro 3D models). Therefore, CoE-NBT will integrate and further enhance the mature scientific and high-technological skills in Life Sciences & Health sector available in the surrounding ecosystem.

CoE-NBT will be equipped with state-of-the art instrumentation and organized in 3 open access facilities usable to external researchers and companies at national and European level. Biofabrication Lab: devoted to the fabrication of implantable and injectable 3D biomimetic scaffolds. Including, high-resolution digital light processing printers, 3D printers based on fused polymer deposition or two-photon polymerization, computer numerical control micromilling, laser-FIB, reactive ion etching, laser lithography. Nanomaterials Lab: devoted to the synthesis of nano- and microparticles. Including, robotic combinatorial synthesis of nanoparticles; automated microwave peptide synthesizer; tangential flow filtration system; high performance liquid and gel permeation chromatography systems for preparative- to analytical-scale isolation, purification, and analysis of multiple types of (bio)molecules. Characterization Lab: devoted to full characterization of nano- and microparticle-integrated 3D biomimetic scaffolds and study of their interactions with living systems. Including, fourier-transform infrared spectroscopy, thermogravimetric analysis, proton nuclear magnetic resonance, atomic force microscope and related spectroscopy, multiphoton microscopy and fluorescence lifetime imaging microscopy, fluorescence activated cell sorting, real-time live-cell metabolic assay platform, raman spectroscopy, cryogenic electron microscopy, secondary ion mass spectrometry.