Activity 10 (A10) represents a cutting-edge endeavor focusing on the innovative utilization of biomaterials to address the clinical requirements of individuals suffering from severe injuries to their central nervous system (CNS), peripheral nervous system (PNS), and musculoskeletal systems. Due to its pioneering nature, this initiative is characterized by a low TRL. The primary mission is to conceptualize and create next-generation intelligent biomaterials capable of efficiently interacting with human tissues, thus aiding and expediting the rehabilitation and rescue processes, particularly for those afflicted with degenerative pathologies or post-traumatic injuries.

The group has identified three specific clinical needs, each corresponding to a vertical project: Neurorehabilitation, Tissue Regeneration and Repair, and Exo-prosthesis Integration/Adoption. All the projects are jointly supervised by clinicians and scientists, ensuring a holistic approach addressing both medical requirements and technological advancements. The overall strategy revolves around the conception and development of functional materials possessing a high degree of informative content and structured functionalities, to either monitor and relay information about tissue status or establish active links between living tissues and artificial systems.

A key strength of A10 relies on the diverse expertise of its partner groups, further strengthened by the installation of two new specialized Centers of Excellence (CoE): the CoE for Advanced Nanobiomaterials and Technologies (CoE-NBT) and the CoE for Biorobotic and Bionic Materials and Systems (CoE-BBMS). These CoEs serve as accelerators of cutting-edge research and innovation, driving advancements in material design and the development of essential components for intelligent biomaterials.

Through collaborative efforts and interdisciplinary research, A10 aims to push the boundaries of biomaterials science, fostering transformative solutions for rehabilitation and rescue processes. By harnessing the potential of intelligent biomaterials and biohybrid interfaces, A10 seeks to provide renewed hope and possibilities for individuals dealing with severe injuries and pathologies, ultimately enhancing their quality of life and restoring functionality.

Loretta L. del Mercato
/ Consiglio Nazionale delle Ricerche
Paolo Netti
/ Università degli Studi di Napoli Federico II
Laura Pastorino
/ Università degli Studi di Genova